Using the Port Dover & Lake Huron Railroad to give my layout a sense of place, the harbour will be Port Dover. Heading north, the top of the plan, is the city of Simcoe. Continuing along the walls of the room you reach Woodstock at the bottom of the plan. Woodstock is where the PD & LH has a junction with the CNR. A track curving off into a corner will simulate the CNR.
